Imisopasem manganese ( M-40403;GC-4419 )

产品货号. M13490 CAS No. 218791-21-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Imisopasem manganese
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A small-molecule superoxide dismutase (SOD) mimetic that converts superoxide to hydrogen peroxide and molecular oxygen.
产品描述

A small-molecule superoxide dismutase (SOD) mimetic that converts superoxide to hydrogen peroxide and molecular oxygen; significantly mitigates the increased sensitivity of old fibroblasts to ionizing radiation and chemotherapy and partially restores mitochondrial function without affecting ionizing radiation or chemotherapy-induced cancer cell killing.Chemotherapeutic Agents Phase 2 Clinical
同义词

M-40403;GC-4419
通路

Others
靶点

Other Targets
受体

Other Targets
研究领域

Cancer
适应症

Chemotherapeutic

CAS Number

218791-21-0
分子量

479.35
分子式

C21H31Cl2MnN5
纯度

>98% (HPLC)
溶解度

H2O: 16 mg/mL (Need ultrasonic and warming)
SMILES

[H][N@]1([C@H]2[C@H]3CCCC2)CC4=[N]5C(C[N]6([H])[C@H]7CCCC[C@H]7[N@@]([Mn]861(Cl)5Cl)([H])CC[N@@]38[H])=CC=C4
化学全称

Manganese, dichloro[(4aR,13aR,17aR,21aR)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-11,7-nitrilo-7H-dibenzo[b,h][1,4,7,10]tetraazacycloheptadecine-κN5,κN13,κN18,κN21,κN22]-, (PB-7-11-2344'3')-

1. Tuder RM, et al. Am J Respir Cell Mol Biol. 2003 Jul;29(1):88-97.
2. Mapuskar KA, et al. Cancer Res. 2017 Aug 1. pii: canres.0106.2017.

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